botox for overactive bladder

 Patients with overactive bladder (OAB) and urgency incontinence (UI), particularly those who are not responsive to first-line medications, may be candidates for intravesical botulinum toxin type A (BoNT-A) injections. Patients with OAB generally have urinary frequencies in excess of seven per 24 hours and nocturia greater than two times per night. For patients with urgency incontinence, the hallmark symptoms are a sudden sensation of urgency to void; the inability to defer urination even though the bladder may or may not be full; and involuntary loss of urine. Although there is no standard definition for OAB syndrome, it includes patients with urgency UI, urge frequency, and urge incontinence.


Intravesical BoNT-A injection into the bladder wall is a well-established treatment for OAB and UI. The efficacy of this treatment is similar to that achieved by anticholinergic medication, but the onset of action can be rapid. Also, a single intravesical injection can provide results for up to six months.


The mechanism of action of BoNT-A in OAB/UI is not completely understood. It appears to act via prejunctional inhibition of acetylcholine release from efferent ch

Location: Amerika Birleşik Devletleri

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